Endocrine Abstracts

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor derived from the thyroid C cells producing calcitonin, ac-counts for 0.6% of all thyroid cancers. It occurs either sporadically or in a hereditary form (RET mutation). MTC can be cured only by complete resection of the thyroid tumor and any loco-regional metastases. Calcitonin (CT) measurement is crucial to the early diagnosis and the follow-up of MTC. If the evaluation of stimulated CT levels is required, a prov...

Abstract: Medullary thyroid cancer (MTC) is a highly aggressive neuroendocrine tumour originating in the thyroid parafollicular cells. Calcitonin measurement and RET gene ascertainment have been used as markers for early diagnosis of MTC. Since pentagastrin is not available, calcium stimulation test helps to preclude ‘gray zone’ values of basal calcitonin, diagnose minimal residual disease and help the early diagnosis of C cell hyperplasia.Aim:...

Introduction: The current revised medullary thyroid carcinoma (MTC) guidelines don’t specify reference ranges of basal (bCT) or stimulated serum calcitonin (sCT) levels for the diagnosis of MTC. These are important for early diagnosis and correct management.Objective: We aimed to set gender specific thresholds for bCT and sCT for MTC diagnosis.Patients and methods: CT samples during calcium-stimulation test (2...

Introduction: Medullary thyroid cancer (MTC) is a neuroendocrine tumor of the parafollicular or C cells of the thyroid gland. While thyroid cancer is increasingly common worldwide, MTC still has a low incidence. We present a case of a seventy-one-years-old woman who presented in our unit after an axillary adenopathy biopsy which tested sparsely positive for KeratinPan, CK7, CEA, TTF1, Chromogranin, Snaptophysin and calcitonin, focal positive for EMA, PAX8, Ki67 30%. Also multi...

Background: Overt parathyroid bone disease is a rare entity. We present a case of primary hyperparathyroidism (PHPT) and osteitis fibrosa cystica with involvement of multiple facial bones and neurocranium. Although the initial differential diagnosis was between acromegaly and bone malignancy, endocrine assessment demonstrated PHPT, with favorable outcome after parathyroidectomy.Case report: A 59-year-old woman referred to our clinic with painful swelling...

Introduction: The metabolic complications in adrenal tumors, regardless secretor or not, are a common finding, thus representing a supplementary warning in these patients related to the non-endocrine therapy as anti-hypertensives, or hypolipemiants drugs, etc.Aim: We analyze the frequency of metabolic complications in primitive adrenal tumors.Materials and methods: This is a retrospective study in patients diagnosed with adrenal tu...

IntroductionOver time, different substances and protocols have been used and tested for stimulating calcitonin (CT). Some of them proved to be useful in diagnosing medullary thyroid carcinoma (MTC). However, these are associated with side-effects, with various duration, intensity and severity.ObjectiveTo report the side-effects observed during CT stimulation test with calcium (Ca) gluconate.<p class="abst...

Introduction: We describe a patient with Cushing’s disease caused by a pituitary macroadenoma treated by double transsphenoidal surgery, stereotactic radiosurgery and steroidogenesis inhibitors and also the challenging management of a patient with multiple comorbidities, including chronic leg ulcers, which are related to increased morbidity and health costs.Case report: In October 2019, a 67-year-old patient presented with intense headache, left tem...

Background: Subacute thyroiditis, autoimmune thyroiditis and an atypical form of thyroiditis due to primary injury of the thyroid gland by SARS Cov2 itself are complications of COVID-19. Angiotensin-converting enzyme 2 is also expressed in the thyroid gland. On the other hand, both untreated thyrotoxicosis and COVID-19 affects heart, generating cardiac complications.Case report: A 36-year-old woman resident in an iodine sufficient area, heavy smoker, pre...

Introduction: Thresholds of basal (bCT) or stimulated serum calcitonin (sCT) levels for the diagnosis of medullary thyroid carcinoma (MTC) aren’t specified in current revised MTC guidelines.Objective: We aim to setfemale (F) specific thresholds for bCT and sCT for MTC diagnosis.Methods: CT samples were measured during calcium-stimulation test (25 mg/kg BW adapted to ideal body mass index) before and at 2, 5 and 10 minutes afte...